| http://purl.uniprot.org/citations/14567558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14567558 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary alceolar proteinosis (PAP) is an autoimmune lung disease characterized by accumulation of surfactant material within the lung. Autoantibodies to GM-CSF as well as high levels of IL-10 are also found in the lungs in PAP. Previous studies suggest that treatment with recombinant GM-CSF is beneficial for patients with low levels of GM-CSF antibodies. The role of IL-10 in PAP, however, is unknown and the hypothesis that IL-10 may affect PAP GM-CSF synthesis has not been addressed. The current findings show that GM-CSF secretion is significantly compromised in PAP bronchoalveolar lavage (BAL) cells compared to controls, but surprisingly, GM-CSF mRNA levels are elevated. In contrast, IL-10 protein and mRNA levels are both highly elevated in PAP. In vitro analysis of GM-CSF regulation indicates that both secretion and mRNA levels are sharply reduced by IL-10 and increased by anti-IL-10 antibody. The phenomenon of elevated GM-CSF mRNA in BAL cells appears not to be due to lack of negative feedback by GM-CSF protein. Results suggest that in PAP, GM-CSF synthesis is deficient and associated with negative regulation by IL-10. Furthermore, IL-10 gene expression becomes even more elevated in patients who do not respond to recombinant GM-CSF therapy and have high anti-GM-CSF titers. Based on these observations, we hypothesize that IL-10 may be an indicator of PAP clinical response to GM-CSF therapy."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.org/dc/terms/identifier | "doi:10.1080/0891693031000152688"xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Abraham S."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Thomassen M.J."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Malur A."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Raychaudhuri B."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Kavuru M.S."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Bonfield T.L."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/author | "Barna B.P."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/pages | "285-290"xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/title | "Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis."xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/14567558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14567558 |
| http://purl.uniprot.org/citations/14567558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14567558 |
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