| http://purl.uniprot.org/citations/14567915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14567915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14567915 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic knockout of the transcriptional corepressor CtBP in mouse embryo fibroblasts upregulates several genes involved in apoptosis. We predicted, therefore, that a propensity toward apoptosis might be regulated through changes in cellular CtBP. To identify pathways involved in this regulation, we screened a mouse embryo cDNA library with an E1A-CtBP complex and identified the homeodomain interacting protein kinase 2 (HIPK2), which had previously been linked to UV-directed apoptosis through its ability to phosphorylate p53. Expression of HIPK2 or exposure to UV irradiation reduced CtBP levels via a proteosome-mediated pathway. The UV effect was prevented by coexpression of kinase-inactive HIPK2 or reduction in HIPK2 levels via siRNA. Mutation of the residue phosphorylated by HIPK2 prevented UV- and HIPK2-directed CtBP clearance. Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00802-x"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00802-x"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Goodman R.H."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Goodman R.H."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Frisch S.M."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Frisch S.M."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Hildebrand J."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Hildebrand J."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Yoshimatsu Y."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/author | "Yoshimatsu Y."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/pages | "177-186"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/pages | "177-186"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/title | "Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/title | "Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP."xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/14567915 | http://purl.uniprot.org/core/volume | "115"xsd:string |