| http://purl.uniprot.org/citations/14570708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14570708 | http://www.w3.org/2000/01/rdf-schema#comment | "During pancreatic organogenesis endocrine cells arise from non self-renewing progenitors that express Ngn3. The precursors that give rise to Ngn3+ cells are presumably located within duct-like structures. However, the nature of such precursors is poorly understood. We show that, at E13-E18, the embryonic stage during which the major burst of beta-cell neogenesis takes place, pancreatic duct cells express Hnf1beta, the product of the maturity-onset diabetes of the young type 5 (MODY5) gene. Ngn3+ cells at this stage invariably cluster with mitotically competent Hnf1beta+ cells, and are often intercalated with these cells in the epithelium that lines the lumen of primitive ducts. We present several observations that collectively indicate that Hnf1beta+ cells are the immediate precursors of Ngn3+ cells. We furthermore show that Hnf1beta expression is markedly reduced in early pancreatic epithelial cells of Hnf6-deficient mice, in which formation of Ngn3+ cells is defective. These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddg355"xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Ferrer J."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Pierreux C.E."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "German M.S."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Rousseau G.G."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Lemaigre F.P."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Boj S.F."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Maestro M.A."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Servitja J.M."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Luco R.F."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/author | "Cabedo J."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/pages | "3307-3314"xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/title | "Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas."xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/14570708 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14570708 |
| http://purl.uniprot.org/citations/14570708 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14570708 |
| http://purl.uniprot.org/uniprot/P22361#attribution-17803F2431009CBDF28A7DD620378218 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14570708 |
| http://purl.uniprot.org/uniprot/P27889#attribution-17803F2431009CBDF28A7DD620378218 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14570708 |
| http://purl.uniprot.org/uniprot/P27889#attribution-63AF5C09AB879CE935CF07779C3EC891 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14570708 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQH4-mappedCitation-14570708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14570708 |
| http://purl.uniprot.org/uniprot/#_P52946-mappedCitation-14570708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14570708 |