| http://purl.uniprot.org/citations/14572439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14572439 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of insulin-like growth factor-I (IGF-I) on cerebellar dysfunction and neurodegeneration were investigated in leaner mice, which exhibit cerebellar ataxia and neurodegeneration related to P/Q-type calcium channel mutations. Leaner mice showed significantly reduced serum and cerebellar IGF-I concentrations compared to wild-type mice at postnatal day 30. Behavioral assessment of leaner mice injected with IGF-I subcutaneously for 4 weeks showed partially improved cerebellar function. Histological analysis of IGF-I treated leaner cerebella showed no difference in the number of dying Purkinje cells compared to control leaner cerebella. These results further support potential use of IGF-I as a therapeutic aid for cerebellar ataxia related to calcium channel mutations. Nonetheless, IGF-I administration does not rescue dying cerebellar neurons, which suggests that the beneficial effects of IGF-I may have been achieved through surviving cerebellar neurons."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-9961(03)00106-2"xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Abbott L.C."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Nahm S.S."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Browning M.D."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Hiney J.K."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Frank T.C."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/author | "Sepulvado J.M."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/pages | "157-165"xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner."xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/14572439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14572439 |
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