| http://purl.uniprot.org/citations/14579314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14579314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14579314 | http://www.w3.org/2000/01/rdf-schema#comment | "The peptide frenatin 3 is a major component of the skin secretion of the Australian giant tree frog, Litoria infrafrenata. Frenatin 3 is 22 amino acids in length, and shows neither antimicrobial nor anticancer activity. It inhibits the production of nitric oxide by the enzyme neuronal nitric oxide synthase at a micromolar concentration by binding to its regulatory protein, Ca2+ calmodulin, a protein known to recognize and bind amphipathic alpha-helices. The solution structure of frenatin 3 has been investigated using NMR spectroscopy and restrained molecular dynamics calculations. In trifluoroethanol/water mixtures, the peptide forms an amphipathic alpha-helix over residues 1-14 while the C-terminal eight residues are more flexible and less structured. The flexible region may be responsible for the lack of antimicrobial activity. In water, frenatin 3 exhibits some alpha-helical character in its N-terminal region."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.org/dc/terms/identifier | "doi:10.1002/bip.10524"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.org/dc/terms/identifier | "doi:10.1002/bip.10524"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Wegener K.L."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Wegener K.L."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Bowie J.H."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Bowie J.H."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Brinkworth C.S."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Brinkworth C.S."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Carver J.A."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Carver J.A."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Doyle J."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Doyle J."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Llewellyn L.E."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/author | "Llewellyn L.E."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/name | "Biopolymers"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/name | "Biopolymers"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/pages | "424-434"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/pages | "424-434"xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/title | "The solution structure of frenatin 3, a neuronal nitric oxide synthase inhibitor from the giant tree frog, Litoria infrafrenata."xsd:string |
| http://purl.uniprot.org/citations/14579314 | http://purl.uniprot.org/core/title | "The solution structure of frenatin 3, a neuronal nitric oxide synthase inhibitor from the giant tree frog, Litoria infrafrenata."xsd:string |