| http://purl.uniprot.org/citations/14583607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14583607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14583607 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 1 is a late-onset neurodegenerative disease caused by the expansion of a CAG triplet repeat in the SCA1 gene. This results in the lengthening of a polyglutamine tract in the gene product ataxin-1. This produces a toxic gain of function that results in specific neuronal death. A region in ataxin-1, the AXH domain, exhibits significant sequence similarity to the transcription factor HBP1. This region of the protein has been implicated in RNA binding and self-association. We have determined the crystal structure of the AXH domain of ataxin-1. The AXH domain is dimeric and contains an OB-fold, a structural motif found in many oligonucleotide-binding proteins, supporting its proposed role in RNA binding. By structure comparison with other proteins that contain an OB-fold, a putative RNA-binding site has been identified. We also identified a cluster of charged surface residues that are well conserved among AXH domains. These residues may constitute a second ligand-binding surface, suggesting that all AXH domains interact with a common yet unidentified partner."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309817200"xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309817200"xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Lowe J."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Lowe J."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Chen Y.W."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Chen Y.W."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Allen M.D."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Allen M.D."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Bycroft M."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Bycroft M."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Veprintsev D.B."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/author | "Veprintsev D.B."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/pages | "3758-3765"xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/pages | "3758-3765"xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/title | "The structure of the AXH domain of spinocerebellar ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/title | "The structure of the AXH domain of spinocerebellar ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14583607 | http://purl.uniprot.org/core/volume | "279"xsd:string |