| http://purl.uniprot.org/citations/14585845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14585845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14585845 | http://www.w3.org/2000/01/rdf-schema#comment | "The peptidoglycan recognition protein Tag7 is shown to form a stable 1:1 complex with the major stress protein Hsp70. Neither protein is cytotoxic by itself, but their complex induces apoptotic death in several tumor-derived cell lines even at subnanomolar concentrations. The minimal part of Hsp70 needed to evoke cytotoxicity is residues 450-463 of its peptide-binding domain, but full cytotoxicity requires its ATPase activity; remarkably, Tag7 liberated from the complex at high ATP is not cytotoxic. The Tag7-Hsp70 complex is produced by tag7-transfected cells and by lymphokine-activated killers, being assembled within the cell and released into the medium through the Golgi apparatus by a mechanism different from the commonly known granule exocytosis. Thus, we demonstrate how a heat shock protein may perform functions clearly distinct from chaperoning or cell rescue and how peptidoglycan recognition proteins may be involved in innate immunity and anti-cancer defense."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m307513200"xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m307513200"xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Gabibov A.G."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Gabibov A.G."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Romanova E.A."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Romanova E.A."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Sashchenko L.P."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Sashchenko L.P."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Yashin D.V."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Yashin D.V."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Georgiev G.P."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Georgiev G.P."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Kiselev S.L."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Kiselev S.L."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Dukhanina E.A."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Dukhanina E.A."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Gnuchev N.V."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Gnuchev N.V."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Kabanova O.D."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Kabanova O.D."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Lukyanova T.I."xsd:string |
| http://purl.uniprot.org/citations/14585845 | http://purl.uniprot.org/core/author | "Lukyanova T.I."xsd:string |