| http://purl.uniprot.org/citations/14586025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14586025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14586025 | http://www.w3.org/2000/01/rdf-schema#comment | "Many bitter stimuli are believed to bind to specific G-protein-coupled membrane receptors on taste cells. Despite the compelling evidence for its pivotal role in bitter taste sensation, a direct involvement of the G-protein subunit alpha-gustducin in bitter taste transduction in taste cells has not been demonstrated in situ at the cellular level. We recorded activation of taste cells by bitter stimuli using Ca2+ imaging in lingual slices and examined alpha-gustducin immunoreactivity in the same cells. In mice vallate papillae, many, but not all, bitter-responsive cells expressed alpha-gustducin. In agreement with this correlation, the incidence of cells responding to bitter stimuli was reduced by 70% in mutant mice lacking alpha-gustducin. Nevertheless, some taste cells lacking alpha-gustducin responded to bitter stimuli, suggesting that other G-protein alpha subunits are involved. We found that the G-protein alpha subunit Galpha(i2) is present in most bitter-responsive cells and thus may also play a role in bitter taste transduction. The reduced behavioral sensitivity to bitter stimuli in alpha-gustducin knock-out mice thus appears to be the consequence of a reduced number of bitter-activated taste cells, as well as reduced sensitivity."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-30-09947.2003"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-30-09947.2003"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Pereira E."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Pereira E."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Margolskee R.F."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Margolskee R.F."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Caicedo A."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Caicedo A."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Roper S.D."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/author | "Roper S.D."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/pages | "9947-9952"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/pages | "9947-9952"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/title | "Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/title | "Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli."xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14586025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14586025 |
| http://purl.uniprot.org/citations/14586025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14586025 |