| http://purl.uniprot.org/citations/14592415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14592415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14592415 | http://www.w3.org/2000/01/rdf-schema#comment | "ABCA7 is expressed predominantly in myelo-lymphatic tissues or reticuloendothelial cells. Physiological role and function of this protein are not fully understood. We isolated the full-length cDNA (type I) and a splicing variant cDNA (type II) of human ABCA7, and developed monoclonal antibodies against extracellular domain (ECD)1 of ABCA7. RT-PCR experiments suggested that human ABCA7 gene produced the type II mRNA in a tissue-specific manner. Immunostaining revealed that the type I ABCA7, expressed in HEK293 cells, was localized to the plasma membrane and ECD1 was exposed to the extracellular space as was the case for ABCA1. HEK293 cells expressing type I ABCA7 showed apoA-I-dependent cholesterol and phospholipid release. In contrast, type II ABCA7 appeared to be localized mainly in endoplasmic reticulum and did not show apoA-I-dependent cholesterol and phospholipid release. Alternative splicing could be involved in the post-transcriptional regulation of the expression and function of human ABCA7."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.10.002"xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.10.002"xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Ueda K."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Ueda K."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Abe-Dohmae S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Abe-Dohmae S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Amachi T."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Amachi T."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Kioka N."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Kioka N."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Kawamoto S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Kawamoto S."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Aoki R."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Aoki R."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Furuya A."xsd:string |
| http://purl.uniprot.org/citations/14592415 | http://purl.uniprot.org/core/author | "Furuya A."xsd:string |