| http://purl.uniprot.org/citations/14593116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14593116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14593116 | http://www.w3.org/2000/01/rdf-schema#comment | "Necdin is a growth suppressor expressed predominantly in postmitotic neurons and implicated in their terminal differentiation. Necdin shows a moderate homology to the MAGE family proteins, the functional roles of which are largely unknown. Human genes encoding necdin, MAGEL2 (necdin-like 1), and MAGE-G1 (necdin-like 2) are located in proximal chromosome 15q, a region associated with neurodevelopmental disorders such as Prader-Willi syndrome, Angelman syndrome, and autistic disorder. The necdin and MAGEL2 genes are subjected to genomic imprinting and suggested to be involved in the etiology of Prader-Willi syndrome. In this study, we compared biochemical and functional characteristics of murine orthologs of these necdin-related MAGE proteins. The colony formation and bromodeoxyuridine incorporation analyses revealed that necdin and MAGE-G1, but not MAGEL2, induced growth arrest. Necdin and MAGE-G1 interacted with the transcription factor E2F1 via its transactivation domain, repressed E2F1-dependent transcription, and antagonized E2F1-induced apoptosis of N1E-115 neuroblastoma cells. In addition, necdin and MAGE-G1 interacted with the p75 neurotrophin receptor via its distinct intracellular domains. In contrast, MAGEL2 failed to bind to these necdin interactors, suggesting that MAGEL2 has no necdin-like function in developing brain. Overexpression of p75 translocated necdin and MAGE-G1 in the proximity of the plasma membrane and reduced their association with E2F1 to facilitate E2F1-induced death of neuroblastoma cells. These results suggest that necdin and MAGE-G1 target both E2F1 and p75 to regulate cell viability during brain development."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308454200"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308454200"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Taniura H."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Taniura H."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Yoshikawa K."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Yoshikawa K."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Kuwako K."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/author | "Kuwako K."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/pages | "1703-1712"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/pages | "1703-1712"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/title | "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/title | "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor."xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14593116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14593116 |
| http://purl.uniprot.org/citations/14593116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14593116 |
| http://purl.uniprot.org/citations/14593116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14593116 |
| http://purl.uniprot.org/citations/14593116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14593116 |