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| http://purl.uniprot.org/citations/14593184 | http://www.w3.org/2000/01/rdf-schema#comment | "In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1090842"xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Hattori D."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Fan G."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Sun Y.E."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Fouse S."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/author | "Martinowich K."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/pages | "890-893"xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/title | "DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation."xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://purl.uniprot.org/core/volume | "302"xsd:string |
| http://purl.uniprot.org/citations/14593184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14593184 |
| http://purl.uniprot.org/citations/14593184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14593184 |
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