| http://purl.uniprot.org/citations/14595118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14595118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14595118 | http://www.w3.org/2000/01/rdf-schema#comment | "While searching for potential candidate molecules relevant for the pathogenesis of endometriosis, we discovered a 2910-base pair cDNA encoding a novel putative 411-amino acid integral membrane protein that we called shrew-1. The putative open-reading frame was confirmed with antibodies against shrew-1 peptides that labeled a protein of approximately 48 kDa in extracts of shrew-1 mRNA-positive tissue and also detected ectopically expressed shrew-1. Expression of epitope-tagged shrew-1 in epithelial cells and analysis by surface biotinylation and immunoblots demonstrated that shrew-1 is indeed a transmembrane protein. Shrew-1 is able to target to E-cadherin-mediated adherens junctions and interact with the E-cadherin-catenin complex in polarized MCF7 and Madin-Darby canine kidney cells, but not with the N-cadherin-catenin complex in nonpolarized epithelial cells. Direct interaction of shrew-1 with beta-catenin in in vitro pull-down assay suggests that beta-catenin might be one of the proteins that targets and/or retains shrew-1 in the adherens junctions. Interestingly, shrew-1 was partially translocated in response to scatter factor (ligand of receptor tyrosine kinase c-met) from the plasma membrane to the cytoplasm where it still colocalized with endogenous E-cadherin. In summary, we introduce shrew-1 as a novel component of adherens junctions, interacting with E-cadherin-beta-catenin complexes in polarized epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-05-0281"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-05-0281"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Baumann R."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Baumann R."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Bharti S."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Bharti S."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Handrow-Metzmacher H."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Handrow-Metzmacher H."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Starzinski-Powitz A."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Starzinski-Powitz A."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Zeitvogel A."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Zeitvogel A."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Zickenheiner S."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/author | "Zickenheiner S."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/pages | "397-406"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/pages | "397-406"xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/title | "Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/14595118 | http://purl.uniprot.org/core/title | "Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells."xsd:string |