| http://purl.uniprot.org/citations/14597164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597164 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteasome is a large multisubunit complex involved in intracellular proteolysis in antigen processing for loading MHC class I molecules. Two activators PA28-alpha and PA28-beta, which are induced by interferon-gamma (IFN-gamma), activate this latent enzyme complex. Genes encoding these activators, PSME1 and PSME2, respectively, have been characterized from various mammalian but only from zebrafish among piscine. We have cloned a PSME2 gene homologue from a leukocyte cDNA library of flounder, a marine fish. The flounder PSME2 gene (fPSME2) encompasses 1063 nucleotides and encodes a polypeptide of 242 amino acids (aa), with a deduced molecular weight of 27.2 kDa. The deduced protein has 82% sequence similarity to that of zebrafish and 73-74% sequence similarity to that of various mammalians and shows higher level sequence homology in the C-terminal region. There was a PA28-beta protein subunit-specific insert located at the corresponding to the KEKE motif of PA28-alpha protein. A phylogenetic tree derived using deduced amino acid sequences showed a diversion of piscine PSME2 from mammalian counterpart after diversion of PSME1 and PSME2 from a common ancestral gene. Northern blot analysis revealed a higher level expression of fPSME2 gene in kidney, spleen and muscle tissues of bacterial lipopolysaccharide (LPS) stimulated flounder than those from non-induced flounder."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2003.08.005"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2003.08.005"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Choi T.J."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Choi T.J."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Kim Y.T."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Kim Y.T."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Hong B.Y."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/author | "Hong B.Y."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/pages | "611-616"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/pages | "611-616"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/title | "Cloning and sequence analysis of cDNA for the proteasome activator PA28-beta subunit of flounder (Paralichthys olivaceus)."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/title | "Cloning and sequence analysis of cDNA for the proteasome activator PA28-beta subunit of flounder (Paralichthys olivaceus)."xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/14597164 | http://purl.uniprot.org/core/volume | "40"xsd:string |