| http://purl.uniprot.org/citations/14597715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597715 | http://www.w3.org/2000/01/rdf-schema#comment | "Fc receptor homolog 4 (FcRH4) is a B cell-specific member of the recently identified family of FcRHs whose intracellular domain contains three potential immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The signaling potential of this receptor, shown here to be preferentially expressed by memory B cells, was compared with the inhibitory receptor FcgammaRIIb in B cells expressing either WT FcgammaRIIb or chimeric proteins in which the intracellular domain of FcRH4 was fused to the transmembrane and extracellular domains of FcgammaRIIb. Coligation of the FcgammaRIIb/FcRH4 chimeric protein with the B cell receptor (BCR) led to tyrosine phosphorylation of the two membrane-distal tyrosines and profound inhibition of BCR-mediated calcium mobilization, whole cell tyrosine phosphorylation, and mitogen-activated protein (MAP)-kinase activation. Mutational analysis of the FcRH4 cytoplasmic region indicated that the two membrane-distal ITIMs are essential for this inhibitory potential. Phosphopeptides corresponding to these ITIMs could bind the Src homology 2 (SH2) domain-containing tyrosine phosphatases SHP-1 and SHP-2, which associated with the WT FcRH4 and with mutants having inhibitory capability. These findings indicate the potential for FcRH4 to abort B cell receptor signaling by recruiting SHP-1 and SHP-2 to its two membrane distal ITIMs."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1935944100"xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1935944100"xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Cooper M.D."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Cooper M.D."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Davis R.S."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Davis R.S."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Hsu J.T."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Hsu J.T."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Ehrhardt A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Ehrhardt A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Ehrhardt G.R.A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Ehrhardt G.R.A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Leu C.-M."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/author | "Leu C.-M."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/pages | "13489-13494"xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/pages | "13489-13494"xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/title | "The inhibitory potential of Fc receptor homolog 4 on memory B cells."xsd:string |
| http://purl.uniprot.org/citations/14597715 | http://purl.uniprot.org/core/title | "The inhibitory potential of Fc receptor homolog 4 on memory B cells."xsd:string |