| http://purl.uniprot.org/citations/14597732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597732 | http://www.w3.org/2000/01/rdf-schema#comment | "The interaction of L-selectin expressed on lymphocytes with sulfated sialomucin ligands such as CD34 and GlyCAM-1 on high endothelial venules (HEV) of lymph nodes results in lymphocyte rolling and is essential for lymphocyte recruitment. HEC-GlcNAc6ST-deficient mice lack an HEV-restricted sulfotransferase with selectivity for the C-6 position of N-acetylglucosamine (GlcNAc). HEC-GlcNAc6ST-/-animals exhibit faster lymphocyte rolling and reduced lymphocyte sticking in HEV, accounting for the diminished lymphocyte homing. Isolated CD34 and GlyCAM-1 from HEC-GlcNAc6ST-/-animals incorporate approximately 70% less sulfate than ligands from wild-type animals. Furthermore, these ligands exhibit a comparable reduction of the epitope recognized by MECA79, a function-blocking antibody that reacts with L-selectin ligands in a GlcNAc-6-sulfate-dependent manner. Whereas MECA79 dramatically inhibits lymphocyte rolling and homing to lymph nodes in wild-type mice, it has no effect on HEC-GlcNAc6ST-/-mice. In contrast, in vitro rolling on purified GlyCAM-1 from HEC-GlcNAc6ST-/-mice, although greatly diminished compared with that on the wild-type ligand, is inhibited by MECA79. Our results demonstrate that HEC-GlcNAc6ST contributes predominantly, but not exclusively, to the sulfation of HEV ligands for L-selectin and that alternative, non-MECA79-reactive ligands are present in the absence of HEC-GlcNAc6ST."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20030057"xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20030057"xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Rosen S.D."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Rosen S.D."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Bistrup A."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Bistrup A."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Gauguet J.-M."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Gauguet J.-M."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Tsay D."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "Tsay D."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "van Zante A."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "van Zante A."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/pages | "1289-1300"xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/pages | "1289-1300"xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/title | "Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse."xsd:string |
| http://purl.uniprot.org/citations/14597732 | http://purl.uniprot.org/core/title | "Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse."xsd:string |