| http://purl.uniprot.org/citations/14597734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14597734 | http://www.w3.org/2000/01/rdf-schema#comment | "Human membrane cofactor protein (CD46) protects host cells against complement attack and may function as a receptor for pathogenic Neisseriae. We assessed CD46 expression in the human cervical cell line ME-180 after exposure to Neisseria gonorrhoeae. Piliated but not nonpiliated gonococci adhered to cells and produced up to an 80% reduction in CD46 surface expression by 6 h that persisted for at least 24 h. This response required a minimum multiplicity of infection of 10 and was not prevented by antibodies to CD46. CD46 down-regulation was not attributable to intracellular retention or a global or specific shutdown of mRNA or protein synthesis. Substantial quantities of CD46 were found in the supernatants, indicating a specific shedding of this protein. Adherent gonococci lacking the pilus retraction protein PilT did not down-regulate CD46 but de-repression of pilT expression restored CD46 down-regulation. After experimental infection of human volunteers with a gonococcal variant incapable of inducing CD46 down-regulation, variants of this strain were reisolated that exhibited CD46 down-regulation. Pilus-mediated interactions of gonococci with human epithelial cells results in a pathogen-induced manipulation of the host cell environment in which a membrane protein is removed from epithelial cells by liberation into the surrounding milieu."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031159"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031159"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Koomey M."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Koomey M."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Cannon J.G."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Cannon J.G."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Gill D.B."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/author | "Gill D.B."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/pages | "1313-1322"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/pages | "1313-1322"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/title | "Down-regulation of CD46 by piliated Neisseria gonorrhoeae."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/title | "Down-regulation of CD46 by piliated Neisseria gonorrhoeae."xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/14597734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14597734 |
| http://purl.uniprot.org/citations/14597734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14597734 |