| http://purl.uniprot.org/citations/14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14601650 | http://www.w3.org/2000/01/rdf-schema#comment | "Deficient DNA mismatch repair results in microsatellite instability and might induce shifts of translational reading frames of genes encompassing coding microsatellites. These may be translated in truncated proteins, including neo-peptide tails functioning as tumor rejection antigens, when presented in the context of MHC class I. Recently, others and we identified a frameshift mutation in the coding T(10) microsatellite of the O-linked N-acetylglucosamine transferase gene (OGT) occuring in up to 41% of microsatellite unstable colorectal cancers. Here we describe a novel HLA-A0201-restricted cytotoxic T lymphocyte (CTL)-epitope (28-SLYKFSPFPL; FSP06) derived from this mutant OGT-protein. FSP06-specific CTL-clones killed peptide-sensitized target cells and tumor cell lines expressing both HLA-A0201 and mutant OGT proteins. This demonstrates that FSP06 is endogenously expressed and represents a CD8(+)-T cell epitope. Our data corroborate the concept of frameshift peptides constituting a novel subset of tumor-associated antigens specifically encountered in cancer cells with deficient mismatch repair."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.org/dc/terms/identifier | "doi:10.1023/a:1025329819121"xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/author | "von Knebel Doeberitz M."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/author | "Gebert J."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/author | "Schwitalle Y."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/author | "Linnebacher M."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/author | "Ripberger E."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/name | "J Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/pages | "415-423"xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/title | "Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene."xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14601650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14601650 |
| http://purl.uniprot.org/citations/14601650 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
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| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
| http://purl.uniprot.org/uniprot/#_A0A0A0YLW6-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C852-mappedCitation-14601650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14601650 |