| http://purl.uniprot.org/citations/14602681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14602681 | http://www.w3.org/2000/01/rdf-schema#comment | "bullwinkle (bwk) regulates embryonic anteroposterior patterning and, through a novel germline-to-soma signal, morphogenesis of the eggshell dorsal appendages. We screened for dominant modifiers of the bullwinkle mooseantler eggshell phenotype and identified shark, which encodes an SH2-domain, ankyrin-repeat tyrosine kinase. At the onset of dorsal-appendage formation, shark is expressed in a punctate pattern in the squamous stretch cells overlying the nurse cells. Confocal microscopy with cell-type-specific markers demonstrates that the stretch cells act as a substrate for the migrating dorsal-appendage-forming cells and extend cellular projections towards them. Mosaic analyses reveal that shark is required in follicle cells for cell migration and chorion deposition. Proper shark RNA expression in the stretch cells requires bwk activity, while restoration of shark expression in the stretch cells suppresses the bwk dorsal-appendage phenotype. These results suggest that shark plays an important downstream role in the bwk-signaling pathway. Candidate testing implicates Src42A in a similar role, suggesting conservation with a vertebrate signaling pathway involving non-receptor tyrosine kinases."xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00854"xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/author | "Tran D.H."xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/author | "Berg C.A."xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/pages | "6273-6282"xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/title | "bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis."xsd:string |
| http://purl.uniprot.org/citations/14602681 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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