| http://purl.uniprot.org/citations/14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14602720 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium channel beta subunits are essential regulatory elements of the gating properties of high voltage-activated calcium channels. Co-expression with beta(3) subunits typically accelerates inactivation, whereas co-expression with beta(4) subunits results in a slowly inactivating phenotype. Here, we have examined the molecular basis of the differential effect of these two subunits on the inactivation characteristics of Ca(v)2.2 + alpha(2)-delta(1) N-type calcium channels by creating a series of 22 chimeric beta subunits that are based on various combinations of variable and conserved regions of the parent beta subunit isoforms. Our data show that replacement of the N terminus region of beta(4) with a corresponding 14-amino acid stretch of beta(3) sequence accelerates the inactivation kinetics to levels seen with wild type beta(3). A similar kinetic speeding is observed by a concomitant substitution of the second conserved and variable regions, but not when these regions are substituted individually, suggesting that 1) the second variable and conserved regions cooperatively regulate N-type calcium channel inactivation and 2) that there are two redundant mechanisms that allow the beta(3) subunit to accelerate N-type channel inactivation. In contrast with previous reports in Ca(v)2.1 calcium channels, deletion of the C-terminal region of Ca(v)2.2 did not alter the regulation of the channel by wild type and chimeric beta subunits. Hence, the molecular underpinnings of beta subunit regulation of voltage-gated calcium channels appear to vary with calcium channel subtype."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308991200"xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "Stotz S.C."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "McRory J.E."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "Zamponi G.W."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "Jarvis S.E."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/author | "Barr W."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/pages | "3793-3800"xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/title | "Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit."xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14602720 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14602720 |
| http://purl.uniprot.org/citations/14602720 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14602720 |
| http://purl.uniprot.org/uniprot/#_P54289-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_B7Z658-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_E7ERK3-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_O95026-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_Q00975-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_Q59FJ3-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_Q9UIU0-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_Q9HAT3-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |
| http://purl.uniprot.org/uniprot/#_Q9HAT4-mappedCitation-14602720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14602720 |