| http://purl.uniprot.org/citations/14604964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14604964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14604964 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI) on mast cells induces a number of biochemical events, including protein-tyrosine phosphorylation leading to degranulation and multiple cytokine gene transcription. Here, we have demonstrated that a second member of the Cbl family of ubiquitin-protein ligase Cbl-b translocates into the lipid raft after FcepsilonRI engagement. Overexpression of Cbl-b in the lipid raft inhibits FcepsilonRI-mediated degranulation and cytokine gene transcription through the distinct mechanism. A point mutation of Cys373 in the RING finger domain of Cbl-b abrogates the suppression of FcepsilonRI-mediated degranulation but not cytokine gene transcription. The antigen-induced tyrosine phosphorylation of FcepsilonRI, Syk, phospholipase C-gamma (PLC-gamma), activation of c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase (ERK), inhibitor of nuclear factor kappaB kinase (IKK), and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft. In particular, the expression amount of Gab2 protein and thereby its FcepsilonRI-mediated tyrosine phosphorylation were dramatically down-regulated by ubiquitin-protein ligase activity of Cbl-b. These results suggest that Cbl-b is a negative regulator of both Lyn-Syk-LAT and Gab2mediated complementary signaling pathways in FcepsilonRI-mediated mast cell activation."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-07-2260"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-07-2260"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Kyo S."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Kyo S."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Maeno K."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Maeno K."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Miah S.M."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Miah S.M."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Qu X."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Qu X."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Sada K."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Sada K."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/pages | "1779-1786"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/pages | "1779-1786"xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/title | "Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b."xsd:string |
| http://purl.uniprot.org/citations/14604964 | http://purl.uniprot.org/core/title | "Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b."xsd:string |