| http://purl.uniprot.org/citations/14604969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14604969 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms regulating the homing/mobilization of hematopoietic stem/progenitor cells (HSPCs) are not fully understood. In our previous studies we showed that the complement C3 activation peptide, C3a, sensitizes responses of HSPCs to stromal-derived factor 1 (SDF-1). In this study, mobilization was induced with granulocyte colony-stimulating factor (G-CSF) in both C3-deficient (C3-/-) and C3a receptor-deficient (C3aR-/-) mice as well as in wild-type (wt) mice in the presence or absence of a C3aR antagonist, SB 290157. The data indicated (1) significantly increased G-CSF-induced mobilization in C3-/- and C3aR-/-mice compared with wt mice, (2) significantly accelerated and enhanced G-CSF-induced mobilization in wt, but not in C3-/- or C3aR-/-, mice treated with SB 290157, and (3) deposition of C3b/iC3b fragments onto the viable bone marrow (BM) cells of G-CSF-treated animals. Furthermore, mobilization studies performed in chimeric mice revealed that wt mice reconstituted with C3aR-/- BM cells, but not C3aR-/-mice reconstituted with wt BM cells, are more sensitive to G-CSF-induced mobilization, suggesting that C3aR deficiency on graft-derived cells is responsible for this increased mobilization. Hence we suggest that C3 is activated in mobilized BM into C3a and C3b, and that the C3a-C3aR axis plays an important and novel role in retention of HSPCs (by counteracting mobilization) by increasing their responsiveness to SDF-1, the concentration of which is reduced in BM during mobilization. The C3a-C3aR axis may prevent an uncontrolled release of HSPCs into peripheral blood. These data further suggest that the C3aR antagonist SB 290157 could be developed as a drug to mobilize HSPCs for transplantation."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-06-2099"xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Janowska-Wieczorek A."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Kucia M."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Ratajczak J."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Ratajczak M.Z."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Wetsel R.A."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Ross G.D."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Majka M."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Reca R."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Allendorf D.J."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/author | "Baran J.T."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/pages | "2071-2078"xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/title | "Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow."xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/14604969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14604969 |
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