| http://purl.uniprot.org/citations/14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14605214 | http://www.w3.org/2000/01/rdf-schema#comment | "The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes play crucial roles in the activation of the ATR-mediated DNA damage and DNA replication stress response pathways. In response to DNA damage, Rad9 is recruited to chromatin in a Rad17-dependent manner in human cells. However, the DNA structures recognized by the Rad17-Rfc2-5 complex during the damage response have not been defined. Here, we show that replication protein A (RPA) stimulates the binding of the Rad17-Rfc2-5 complex to single-stranded DNA (ssDNA), primed ssDNA, and a gapped DNA structure. Furthermore, RPA facilitates the recruitment of the Rad9-Rad1-Hus1 complex by the Rad17-Rfc2-5 complex to primed and gapped DNA structures in vitro. These findings suggest that RPA-coated ssDNA is an important part of the structures recognized by the Rad17-Rfc2-5 complex. Unlike replication factor C (RFC), which uses the 3' primer/template junction to recruit proliferating cell nuclear antigen (PCNA), the Rad17-Rfc2-5 complex can use both the 5' and the 3' primer/template junctions to recruit the Rad9-Rad1-Hus1 complex, and it shows a preference for gapped DNA structures. These results explain how the Rad17-Rfc2-5 complex senses DNA damage and DNA replication stress to initiate checkpoint signaling."xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2336100100"xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/author | "Zou L."xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/pages | "13827-13832"xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/title | "Replication protein A-mediated recruitment and activation of Rad17 complexes."xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/14605214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14605214 |
| http://purl.uniprot.org/citations/14605214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14605214 |
| http://purl.uniprot.org/uniprot/#_O75943-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P15927-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P40937-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P40938-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_O60671-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_O60921-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_Q08949-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P27694-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P35244-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P35249-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_P35250-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |
| http://purl.uniprot.org/uniprot/#_Q6WBX8-mappedCitation-14605214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14605214 |