| http://purl.uniprot.org/citations/14607906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14607906 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-15Ralpha-deficient (IL-15Ralpha(-/-)) mice lack NK cells. However, when bone marrow (BM) progenitors from IL-15Ralpha(-/-) mice were cultured with IL-7, stem cell factor and flt3 ligand, followed by IL-15, they were able to differentiate into functional NK cells, indicating that IL-15Ralpha is not critical for NK cell development. Whereas NK cells generated in vitro from IL-15Ralpha(-/-) BM progenitors expressed CD94/NKG2, they failed to express Ly-49 receptors. In keeping with this, when IL-15Ralpha(-/-) BM cells were transferred into wild type recipients, they gave rise to NK cells in vivo, but with greatly reduced expression of Ly-49 receptors. Furthermore, the small numbers of NK cells found in IL-15(-/-) as well as IL-15Ralpha(-/-) but not flt3 ligand(-/-) mice expressed much lower levels of Ly-49 receptors than those from wild type mice. These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.10.5085"xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/author | "Kawamura T."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/author | "Ma A."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/author | "Koka R."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/pages | "5085-5090"xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/title | "Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction."xsd:string |
| http://purl.uniprot.org/citations/14607906 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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