| http://purl.uniprot.org/citations/14607908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14607908 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic negative selection and contraction of responding T cell oligoclones after infection represent important cell ablation processes required for maintaining T cell homeostasis. It has been proposed that galectin 1 contributes to these processes through interaction with lactosyl sequences principally on cell surface glycoproteins bearing core 2 (C2GnT1)-branched O-glycans. According to this model, specific T cell surface proteins cross-linked by galectin 1 induce signaling, ligand redistribution, and apoptosis in both immature thymocytes and activated T cells. The influence of lactosyl residues contained in branched O-glycans or complex N-glycans on galectin 1 binding and induction of annexin V ligand in murine CD8 T cells was assessed. Neither galectin binding nor galectin-induced expression of annexin V ligand was perturbed under conditions in which: 1) C2GnT1 activity was differentially induced by CD8 T cell activation/culture with IL-2 vs IL-4; 2) activated CD8(+) T cells lacked C2GnT1 expression; or 3) complex N-glycan formation was blocked by swainsonine. The maintenance of galectin 1 binding and induced annexin V expression under conditions that alter lactosamine abundance on O- or complex N-glycans suggest that galectin 1-mediated apoptosis is neither a simple function of fluctuating C2GnT1 activity nor a general C2GnT1-dependent mechanism underlying contraction of CD8 T cells subsequent to activation."xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.10.5100"xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/author | "Ziltener H.J."xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/author | "Williams M.J."xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/author | "Carlow D.A."xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/pages | "5100-5106"xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/title | "Modulation of O-glycans and N-glycans on murine CD8 T cells fails to alter annexin V ligand induction by galectin 1."xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/14607908 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14607908 |
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