| http://purl.uniprot.org/citations/14607964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14607964 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient in the enzyme adenosine deaminase (ADA) have small lymphoid organs that contain reduced numbers of peripheral lymphocytes, and they are immunodeficient. We investigated B cell deficiency in ADA-deficient mice and found that B cell development in the bone marrow was normal. However, spleens were markedly smaller, their architecture was dramatically altered, and splenic B lymphocytes showed defects in proliferation and activation. ADA-deficient B cells exhibited a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, suggesting that ADA plays a role in the survival of cells during Ag-dependent responses. In keeping with this finding, IgM production by extrafollicular plasmablast cells was higher in ADA-deficient than in wild-type mice, thus indicating that activated B cells accumulate extrafollicularly as a result of a poor or nonexistent germinal center formation. This hypothesis was subsequently confirmed by the profound loss of germinal center architecture. A comparison of levels of the ADA substrates, adenosine and 2'-deoxyadenosine, as well resulting dATP levels and S-adenosylhomocysteine hydrolase inhibition in bone marrow and spleen suggested that dATP accumulation in ADA-deficient spleens may be responsible for impaired B cell development. The altered splenic environment and signaling abnormalities may concurrently contribute to a block in B cell Ag-dependent maturation in ADA-deficient mouse spleens."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.10.5562"xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Blackburn M.R."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Kellems R.E."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Martinez-Valdez H."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Datta S.K."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/author | "Aldrich M.B."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/pages | "5562-5570"xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/title | "Impaired germinal center maturation in adenosine deaminase deficiency."xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/14607964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14607964 |
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