| http://purl.uniprot.org/citations/14612514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14612514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14612514 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells respond to double-stranded DNA breaks (DSBs) by pausing cell cycle progression to allow the repair machinery to restore genomic integrity. DNA-dependent protein kinase (DNA-PK), comprising a large catalytic subunit (DNA-PK(cs)) and the Ku antigen regulatory subunit (Ku70/Ku80), is activated in response to DSBs and is required for DNA repair through the nonhomologous end-joining pathway. Here we provide evidence that DNA-PK participates in altering specific gene expression in response to DNA damage by modulating the stability and transcriptional regulatory potential of the essential transcription factor octamer transcription factor 1 (Oct-1). Histone H2B and U2 RNA, whose expression are highly dependent on Oct-1, were strongly decreased in response to ionizing radiation in a DNA-PK-dependent manner, and Oct-1-dependent reporter gene transcription was repressed. Furthermore, Oct-1 phosphorylation in response to ionizing radiation increased in a DNA-PK-dependent manner. Paradoxically, down-regulation of transactivation correlated with the rapid DNA-PK-dependent stabilization of Oct-1. Stabilization of Oct-1 was dependent on the NH(2)-terminal region of Oct-1, which contains a transcriptional activation domain and which was phosphorylated by DNA-PK in vitro. These results suggest a mechanism for the regulation of Oct-1 in response to DNA damage through specific phosphorylation within the NH(2)-terminal transcriptional regulatory domain."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Hache R.J.G."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Hache R.J.G."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Shih A."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Schild-Poulter C."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Schild-Poulter C."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Yarymowich N.C."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/author | "Yarymowich N.C."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/pages | "7197-7205"xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/pages | "7197-7205"xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/title | "Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/title | "Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1."xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/14612514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14612514 |
| http://purl.uniprot.org/citations/14612514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14612514 |
| http://purl.uniprot.org/citations/14612514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14612514 |
| http://purl.uniprot.org/citations/14612514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14612514 |