| http://purl.uniprot.org/citations/14615540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14615540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14615540 | http://www.w3.org/2000/01/rdf-schema#comment | "Nova proteins are neuron-specific antigens targeted in paraneoplastic opsoclonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhibition. Nova proteins regulate neuronal pre-messenger RNA splicing by directly binding to RNA. To identify Nova RNA targets, we developed a method to purify protein-RNA complexes from mouse brain with the use of ultraviolet cross-linking and immunoprecipitation (CLIP).Thirty-four transcripts were identified multiple times by Nova CLIP.Three-quarters of these encode proteins that function at the neuronal synapse, and one-third are involved in neuronal inhibition.Splicing targets confirmed in Nova-/-mice include c-Jun N-terminal kinase 2, neogenin, and gephyrin; the latter encodes a protein that clusters inhibitory gamma-aminobutyric acid and glycine receptors, two previously identified Nova splicing targets.Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1090095"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1090095"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ruggiu M."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ruggiu M."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Mele A."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Mele A."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Jensen K.B."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Jensen K.B."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ule A."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/author | "Ule A."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/pages | "1212-1215"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/pages | "1212-1215"xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/title | "CLIP identifies Nova-regulated RNA networks in the brain."xsd:string |
| http://purl.uniprot.org/citations/14615540 | http://purl.uniprot.org/core/title | "CLIP identifies Nova-regulated RNA networks in the brain."xsd:string |