| http://purl.uniprot.org/citations/14617519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14617519 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein A (SP-A) plays a role in innate host defense. Human SP-A is encoded by two functional genes (SP-A1 and SP-A2), and several alleles have been characterized for each gene. We assessed the effect of in vitro expressed human SP-A genetic variants, on TNF-alpha and IL-8 production by THP-1 cells in the presence of bleomycin, either before or after ozone-induced oxidation of the variants. The oligomerization of SP-A variants was also examined. We found 1) cytokine levels induced by SP-A2 (1A, 1A(0)) were significantly higher than those by SP-A1 (6A(2), 6A(4)) in the presence of bleomycin. 2) In the presence of bleomycin, ozone-induced oxidation significantly decreased the ability of 1A and 1A/6A(4), but not of 6A(4), to stimulate TNF-alpha production. 3) The synergistic effect of bleomycin/SP-A, either before or after oxidation, can be inhibited to the level of bleomycin alone by surfactant lipids. 4) Differences in oligomerization were also observed between SP-A1 and SP-A2. The results indicate that differences among SP-A variants may partly explain the individual variability of pulmonary complications observed during bleomycin chemotherapy and/or in an environment that may promote protein oxidation."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00267.2003"xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/author | "Floros J."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/author | "Phelps D.S."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/author | "Al-Mondhiry H."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/pages | "L546-53"xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/title | "Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation."xsd:string |
| http://purl.uniprot.org/citations/14617519 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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