| http://purl.uniprot.org/citations/14617812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14617812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14617812 | http://www.w3.org/2000/01/rdf-schema#comment | "The best described function of the adaptor complex-1 (AP-1) is to participate in the budding of clathrin-coated vesicles from the trans-Golgi network and endosomes. Here, we show that AP-1 is also localized to phagocytic cups in murine macrophages as well as in Dictyostelium amoebae. AP-1 is recruited to phagosomal membranes at this early stage of phagosome formation and rapidly dissociates from maturing phagosomes. To establish the role of AP-1 in phagocytosis, we made used of Dictyostelium mutant cells (apm1(-) cells) disrupted for AP-1 medium chain. In this mutant, phagocytosis drops by 60%, indicating that AP-1 is necessary for efficient phagocytosis. Furthermore, phagocytosis in apm1(-) cells is more affected for large rather than small particles, and cells exhibiting incomplete engulfment are then often observed. This suggests that AP-1 could participate in the extension of the phagocytic cup. Interestingly, macropinocytosis, a process dedicated to fluid-phase endocytosis and related to phagocytosis, is also impaired in apm1(-) cells. In summary, our data suggest a new role of AP-1 at an early stage of phagosome and macropinosome formation."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-06-0365"xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-06-0365"xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Gotthardt D."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Gotthardt D."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Soldati T."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Soldati T."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Aderem A.A."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Aderem A.A."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Bruckert F."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Bruckert F."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Cornillon S."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Cornillon S."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Cosson P."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Cosson P."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Lefkir Y."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Lefkir Y."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Letourneur F."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Letourneur F."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Malbouyres M."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Malbouyres M."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Ozinsky A."xsd:string |
| http://purl.uniprot.org/citations/14617812 | http://purl.uniprot.org/core/author | "Ozinsky A."xsd:string |