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| http://purl.uniprot.org/citations/14623868 | http://www.w3.org/2000/01/rdf-schema#comment | "In sympathetic neurons, unlike most nonneuronal cells, growth factor withdrawal-induced apoptosis requires the development of competence in addition to cytochrome c release to activate caspases. Thus, although most nonneuronal cells die rapidly with cytosolic cytochrome c alone, sympathetic neurons are remarkably resistant unless they develop competence. We have identified endogenous X-linked inhibitor of apoptosis protein (XIAP) as the essential postcytochrome c regulator of caspase activation in these neurons. In contrast to wild-type neurons that are resistant to injection of cytochrome c, XIAP-deficient neurons died rapidly with cytosolic cytochrome c alone. Surprisingly, the release of endogenous Smac was not sufficient to overcome the XIAP resistance in sympathetic neurons. In contrast, the neuronal competence pathway permitted cytochrome c to activate caspases by inducing a marked reduction in XIAP levels in these neurons. Thus, the removal of XIAP inhibition appears both necessary and sufficient for cytochrome c to activate caspases in sympathetic neurons. These data identify a critical function of endogenous XIAP in regulating apoptosis in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200307130"xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/author | "Deshmukh M."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/author | "Potts P.R."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/author | "Knezek M."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/pages | "789-799"xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/title | "Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis."xsd:string |
| http://purl.uniprot.org/citations/14623868 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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