| http://purl.uniprot.org/citations/14623891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14623891 | http://www.w3.org/2000/01/rdf-schema#comment | "The serine proteinase inhibitor tissue factor pathway inhibitor-2 (TFPI-2) inhibits the tissue factor-factor VIIa complex and thereby impairs factor Xa and subsequently thrombin generation. Here we show that thrombin itself up-regulates TFPI-2 mRNA and protein expression in human liver myofibroblasts, a cell type shown to express high levels of TFPI-2 (Neaud, V., Hisaka, T., Monvoisin, A., Bedin, C., Balabaud, C., Foster, D. C., Desmoulière, A., Kisiel, W., and Rosenbaum, J. (2000) J. Biol. Chem. 275, 35565-35569). This effect required thrombin catalytic activity, as shown by its abolition with hirudin. Although the thrombin effect could be mimicked by agonists of both protease-activated receptor (PAR)-1 and PAR-4, it was largely blocked by a PAR-1 blocking antibody. Transactivation of the epidermal growth factor (EGF) receptor has been reported as a common event in thrombin signaling. However, thrombin did not detectably transactivate the EGF receptor in liver myofibroblasts, and blocking the EGF receptor did not affect TFPI-2 induction. On the other hand, thrombin increased the expression of cyclooxygenase-2 (COX-2) mRNA via a MAPK-dependent pathway, and a specific COX-2 inhibitor abolished the effect of thrombin on TFPI-2 expression. Thus, thrombin, through PAR-1 signaling, up-regulates the synthesis of TFPI-2 via a MAPK/COX-2-dependent pathway. The up-regulation of TFPI-2 expression by thrombin could in turn down-regulate thrombin generation and contribute to limit blood coagulation."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306679200"xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/author | "Kisiel W."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/author | "Rosenbaum J."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/author | "Mazzocco C."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/author | "Neaud V."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/author | "Duplantier J.G."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/pages | "5200-5206"xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/title | "Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/14623891 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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