| http://purl.uniprot.org/citations/14624371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14624371 | http://www.w3.org/2000/01/rdf-schema#comment | "The role that host genetics plays in the modification of the rate of human immunodeficiency virus 1 (HIV-1)-related disease progression was evaluated in a seroprevalent cohort of 1049 children with symptomatic HIV-1 infection who participated in 2 clinical trials in the United States. Variants including CCR2-V64I, CCR5-wt/Delta32, CCR5-59029-G/A, CCR5-59353-T/C, CCR5-59356-C/T, and SDF1-3'-G/A were identified by polymerase chain-reaction genotyping. Children with the CCR5-wt/Delta32 genotype experienced significantly delayed disease progression, including less neurocognitive impairment. In the CCR5-wt/wt group, the most rapid disease progression was in those with the CCR5-59029-A/A genotype, which was present in 23% of the children. Although the SDF1-3'-A/A variant was associated with more-rapid disease progression, it occurred in <2% of the children studied. Modest or little impact was associated with the CCR5-59353, CCR5-59356, or CCR2 genotypes. Thus, in children with the CCR5-wt/wt genotype, variants at CCR5-59029 have the broadest impact on disease progression. These data suggest that, in children, host genetics plays an important role in HIV-1-related disease progression and neurological impairment."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.org/dc/terms/identifier | "doi:10.1086/379038"xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Singh K.K."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Barroga C.F."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Spector S.A."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Hughes M.D."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "McKinney R.E."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/author | "Raskino C."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/pages | "1461-1472"xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/title | "Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/14624371 | http://purl.uniprot.org/core/volume | "188"xsd:string |
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