| http://purl.uniprot.org/citations/14625303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14625303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14625303 | http://www.w3.org/2000/01/rdf-schema#comment | "Pre-mRNA splicing removes introns and leaves in its wake a multiprotein complex near the exon-exon junctions of mRNAs. This complex, termed the exon-exon junction complex (EJC), contains at least seven proteins and provides a link between pre-mRNA splicing and downstream events, including transport, localization, and nonsense-mediated mRNA decay. Using a simple whole cell lysate system we developed for in vitro splicing, we prepared lysates from cells transfected with tagged EJC proteins and studied the association of these proteins with pre-mRNA, splicing intermediates, and mRNA, as well as formation of the EJC during splicing. Three of the EJC components, Aly/REF, RNPS1, and SRm160, are found on pre-mRNA by the time the spliceosome is formed, whereas Upf3b associates with splicing intermediates during or immediately after the first catalytic step of the splicing reaction (cleavage of exon 1 and intron-lariat formation). In contrast, Y14 and magoh, which remain stably associated with mRNA after export to the cytoplasm, join the EJC during or after completion of exon-exon ligation. These findings indicate that EJC formation is an ordered pathway that involves stepwise association of components and is coupled to specific intermediates of the splicing reaction."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m307692200"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m307692200"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/author | "Dreyfuss G."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/author | "Kataoka N."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/author | "Kataoka N."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/pages | "7009-7013"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/pages | "7009-7013"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/title | "A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/title | "A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex."xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14625303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14625303 |
| http://purl.uniprot.org/citations/14625303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14625303 |
| http://purl.uniprot.org/citations/14625303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14625303 |
| http://purl.uniprot.org/citations/14625303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14625303 |
| http://purl.uniprot.org/uniprot/Q15287 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14625303 |
| http://purl.uniprot.org/uniprot/Q9Y5S9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14625303 |