| http://purl.uniprot.org/citations/14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14625475 | http://www.w3.org/2000/01/rdf-schema#comment | "Cutaneous burn injury-induced T lymphocyte suppression is a well-known phenomenon. In this study, we evaluated the effect of treatment of burn rats with pentoxifylline (PTX) on the burn-induced suppression of T lymphocytes. Anesthetized rats were subjected to 30% total body surface area burn by exposing skin to 95 degrees C water for 10 s. T lymphocytes were isolated from sham and burn rats with or without PTX treatment (120 mg/kg, ip). T cell proliferation and interleukin (IL)-2 production in response to T cell mitogen concanavalin A was measured using 3 H-thymidine uptake and enzyme-linked immunosorbent assay, respectively. P59 fyn autophosphorylation and its kinase activity was determined using in vitro kinase assay. In addition, T lymphocyte Ca2+ signaling was assessed using Ca2+ imaging technique. Two days after injury, there was a significant decrease in mesenteric lymph node T cell proliferation and IL-2 production in burn injured rats compared with those obtained from sham-injured rats. This decrease in T cell proliferation and IL-2 production in burn-injured rats was accompanied by a significant suppression in both P59 autophophorylation and kinase activity as well as Ca2+ signaling. Treatment of burn-injured rats with PTX produced a near complete recovery of T cell proliferation and IL-2 production. Furthermore, PTX treatment also prevented the burn-mediated suppression in P59fyn and kinase activity as well as restored Ca2+ signaling similar to those observed in sham injured rats. These findings altogether suggested that PTX treatment attenuate T cell suppression in burn-injured rats and that the effects of PTX are mediated via modulating P59 fyn and Ca2+ signaling."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.shk.0000098103.41147.54"xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Haque F."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Sayeed M.M."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Choudhry M.A."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Al-Ghoul W."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Kotadia B.K."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/author | "Ravindranath T.M."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/name | "Shock"xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/pages | "517-520"xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/title | "Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury."xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/14625475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14625475 |
| http://purl.uniprot.org/citations/14625475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14625475 |
| http://purl.uniprot.org/uniprot/Q62844#attribution-50327EC1D78C64E899602BCB32E97E3E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K2E3-mappedCitation-14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/#_A0A096MKC1-mappedCitation-14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/#_A0A096MKC5-mappedCitation-14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A612-mappedCitation-14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/#_Q62844-mappedCitation-14625475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/A0A096MKC5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/A0A0G2K2E3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14625475 |
| http://purl.uniprot.org/uniprot/Q62844 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14625475 |