| http://purl.uniprot.org/citations/14627983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14627983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14627983 | http://www.w3.org/2000/01/rdf-schema#comment | "MAGI-1 and CASK are membrane-associated guanylate kinases of epithelial junctions. MAGI-1 is localized at tight junctions in polarized epithelial cells, whereas CASK is localized along the lateral membranes. We obtained the KIAA0769 gene product through the yeast two-hybrid screening using MAGI-1 as a bait and named it Carom. Carom has a coiled-coil domain in the middle region, and two src homology 3 domains and a PSD-95/Dlg-A/ZO-1 (PDZ)-binding motif in the C-terminal region. Carom binds to the fifth PDZ domain of MAGI-1 and the calmodulin kinase domain of CASK in vitro. MAGI-1 and CASK bind to the distinct sequences in the C-terminal region of Carom, but still compete with each other for Carom binding. The study using a stable transformant of Madine Darby canine kidney (MDCK) cells expressing GFP-Carom revealed that Carom was partially overlapped by MAGI-1 in MDCK cells, which have not yet established mature cell junctions, but became separated from MAGI-1 and colocalized with CASK in polarized cells. Carom was highly resistant to Triton X-100 extractions and recruited CASK to the Triton X-100-insoluble structures. Carom is a binding partner of CASK, which interacts with CASK in polarized epithelial cells and may link it to the cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206996"xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206996"xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Hata Y."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Hata Y."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Tajima M."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Tajima M."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Omata M."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Omata M."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Hirabayashi S."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Hirabayashi S."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Yao I."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Yao I."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Mashima H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Mashima H."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Kansaku A."xsd:string |
| http://purl.uniprot.org/citations/14627983 | http://purl.uniprot.org/core/author | "Kansaku A."xsd:string |