| http://purl.uniprot.org/citations/14630943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14630943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14630943 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterochromatin proteins are thought to play key roles in chromatin structure and gene regulation, yet very few genes have been identified that are regulated by these proteins. We performed large-scale mapping and analysis of in vivo target loci of the proteins HP1, HP1c, and Su(var)3-9 in Drosophila Kc cells, which are of embryonic origin. For each protein, we identified approximately 100-200 target genes among >6000 probed loci. We found that HP1 and Su(var)3-9 bind together to transposable elements and genes that are predominantly pericentric. In addition, Su(var)3-9 binds without HP1 to a distinct set of nonpericentric genes. On chromosome 4, HP1 binds to many genes, mostly independent of Su(var)3-9. The binding pattern of HP1c is largely different from those of HP1 and Su(var)3-9. Target genes of HP1 and Su(var)3-9 show lower expression levels in Kc cells than do nontarget genes, but not if they are located in pericentric regions. Strikingly, in pericentric regions, target genes of Su(var)3-9 and HP1 are predominantly embryo-specific genes, whereas on the chromosome arms Su(var)3-9 is preferentially associated with a set of male-specific genes. These results demonstrate that, depending on chromosomal location, the HP1 and Su(var)3-9 proteins form different complexes that associate with specific sets of developmentally coexpressed genes."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.281503"xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.281503"xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Bussemaker H.J."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Bussemaker H.J."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van Driel R."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van Driel R."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "de Wit E."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "de Wit E."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Henikoff S."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Henikoff S."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Delrow J."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Delrow J."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van Steensel B."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van Steensel B."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van der Kraan I."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "van der Kraan I."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Greil F."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Greil F."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Smothers J.F."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/author | "Smothers J.F."xsd:string |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14630943 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |