| http://purl.uniprot.org/citations/14632928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14632928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14632928 | http://www.w3.org/2000/01/rdf-schema#comment | "A new peptide named Martentoxin I and an analogue Martentoxin were purified and characterized from the venom of Buthus martensi Karch. Martentoxin I consisted of 36 amino acid residues with molecular mass as 3908.0 Da determined by matrix-assisted laser desorption ionization time-of-flight-MS. The amino acid sequence was determined as GLIDVKCFASSECWTACKKVTGSGQGKCQNNQCRCY by Edman degradation. Martentoxin consisted of 37 amino acid residues with a molecular mass as 4055.3 Da and it showed highly sequence identity to Martentoxin I as FGLIDVKCFASSECWTACKKVTGSGQGKCQNNQCRCY. Estimation from circular dichroism spectra indicated Martentoxin I owned 18.0% alpha-helix, 53.0% beta-sheet structure and 3.9% turn while Martentoxin contained 13.3% alpha-helix, 64.3% beta-sheet structure and 1.1% turn. The toxicity assay showed both peptides had no toxic effects on mice up to the dose of 10 mg/kg. Electrophysiological studies showed that Martentoxin I and Martentoxin at the concentration of 1 microm significantly inhibited voltage-dependent Na+ current (INa) and voltage-dependent delayed rectifier K+ current (IK) but had no effects on transient K+ current (IA). Both interactions with Na+ and K+ channels were irreversible."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1399-3011.2003.00095.x"xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1399-3011.2003.00095.x"xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Wang X.L."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Wang X.L."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Liu X.M."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Liu X.M."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Cao Z.Y."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Cao Z.Y."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Yu D.Q."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Yu D.Q."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Liang X.T."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Liang X.T."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Pan Y.P."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Pan Y.P."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Shen W.Q."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/author | "Shen W.Q."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/name | "J. Pept. Res."xsd:string |
| http://purl.uniprot.org/citations/14632928 | http://purl.uniprot.org/core/name | "J. Pept. Res."xsd:string |