| http://purl.uniprot.org/citations/14633987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14633987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14633987 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-kappaB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL-1- and TNF-induced activation of the NF-kappaB pathway. TAB2, a TAK1-binding protein, is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. However, IL-1-induced activation of NF-kappaB is not impaired in TAB2-deficient embryonic fibroblasts. Here we report the identification and characterization of a novel protein designated TAB3, a TAB2-like molecule that associates with TAK1 and can activate NF-kappaB similar to TAB2. Endogenous TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. Further more, IL-1 signaling leads to the ubiquitination of TAB2 and TAB3 through TRAF6. Cotransfection of siRNAs directed against both TAB2 and TAB3 inhibit both IL-1- and TNF-induced activation of TAK1 and NF-kappaB. These results suggest that TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg605"xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg605"xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Takaesu G."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Takaesu G."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Shibuya H."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Shibuya H."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/pages | "6277-6288"xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/pages | "6277-6288"xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/title | "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."xsd:string |
| http://purl.uniprot.org/citations/14633987 | http://purl.uniprot.org/core/title | "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."xsd:string |