| http://purl.uniprot.org/citations/14635195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14635195 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell adhesion molecules play a critical role in cell contacts, whether cell-cell or cell-matrix, and are regulated by multiple signaling pathways. In this report, we identify a novel ring zinc finger-leucine-rich repeat containing protein (RIFLE) and show that RIFLE, expressed in PC12 cells, enhances the Serine (Ser)21/9 phosphorylation of glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) resulting in the inhibition of GSK-3 kinase activity and increase of beta-catenin levels. RIFLE expression also is associated with elevated E-cadherin protein levels but not N-cadherin. The regulation of these cell adhesion-associated molecules by RIFLE is accompanied by a significant increase in cell-cell and cell-matrix adhesion. Moreover, increase in cell-cell adhesion but not cell-matrix adhesion by RIFLE can be mimicked by selective inhibition of GSK-3. Our results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.10674"xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Na S."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Ni B."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/author | "Ryder J."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/pages | "1224-1241"xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/title | "RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells."xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/14635195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14635195 |
| http://purl.uniprot.org/citations/14635195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14635195 |
| http://purl.uniprot.org/uniprot/#_Q6UWE0-mappedCitation-14635195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14635195 |
| http://purl.uniprot.org/uniprot/Q6UWE0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14635195 |