| http://purl.uniprot.org/citations/14637149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14637149 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell proliferation is regulated in part by cell-cell interactions mediated by cadherin and connexin. Here we present evidence that these two molecules act synergistically to suppress HEK293 cell proliferation by prolonging the G2/M phase. This event was accompanied by expression of p21, a potent Cdc2 kinase inhibitor. Not surprisingly, there was a concomitant decline in Cdc2 kinase activity. beta-Catenin/TCF signaling, which was downregulated by overexpression of N-cadherin, was found to inhibit transactivation of p21 gene expression. The effect of N-cadherin on cell proliferation and p21 expression was augmented by co-expression of connexin-43. Moreover, the magnitude of the connexin's effect was dependent on its ability to mediate intercellular communication. We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.10.129"xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/author | "Hori M."xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/author | "Toyofuku T."xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/author | "Kamei J."xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/pages | "380-387"xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/title | "Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/14637149 | http://purl.uniprot.org/core/volume | "312"xsd:string |
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