| http://purl.uniprot.org/citations/14640981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14640981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14640981 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a polypeptide that was already known to interact with polyglutamine-tract-binding protein (PQBP)-1/Npw38 as a novel splicing factor and interactor of protein phosphatase-1, hence the name SIPP1 for splicing factor that interacts with PQBP-1 and PP1 (protein phosphotase 1). SIPP1 was inhibitory to PP1, and its inhibitory potency was increased by phosphorylation with protein kinase CK1. Two-hybrid and co-sedimentation analysis revealed that SIPP1 has two distinct PP1-binding domains and that the binding of SIPP1 with PP1 involves a RVXF (Arg-Val-Xaa-Phe) motif, which functions as a PP1-binding sequence in most interactors of PP1. Enhanced-green-fluorescent-protein-tagged SIPP1 was targeted exclusively to the nucleus and was enriched in the nuclear speckles, which represent storage/assembly sites of splicing factors. We have mapped a nuclear localization signal in the N-terminus of SIPP1, while the proline-rich C-terminal domain appeared to be required for its subnuclear targeting to the speckles. Finally, we found that SIPP1 is also a component of the spliceosomes and that a SIPP1-fragment inhibits splicing catalysis by nuclear extracts independent of its ability to interact with PP1."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20030950"xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20030950"xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Andres I."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Andres I."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Ortiz J.M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Ortiz J.M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Beullens M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Beullens M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Bollen M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Bollen M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Llorian M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/author | "Llorian M."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/pages | "229-238"xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/pages | "229-238"xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/title | "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/title | "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1."xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/volume | "378"xsd:string |
| http://purl.uniprot.org/citations/14640981 | http://purl.uniprot.org/core/volume | "378"xsd:string |