| http://purl.uniprot.org/citations/14642282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14642282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14642282 | http://www.w3.org/2000/01/rdf-schema#comment | "PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 is regulated by the ubiquitin-proteasome pathway. PSD-95 interacts with and is ubiquitinated by the E3 ligase Mdm2. In response to NMDA receptor activation, PSD-95 is ubiquitinated and rapidly removed from synaptic sites by proteasome-dependent degradation. Mutations that block PSD-95 ubiquitination prevent NMDA-induced AMPA receptor endocytosis. Likewise, proteasome inhibitors prevent NMDA-induced AMPA receptor internalization and synaptically induced long-term depression. This is consistent with the notion that PSD-95 levels are an important determinant of AMPA receptor number at the synapse. These data suggest that ubiquitination of PSD-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00687-1"xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00687-1"xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Langeberg L.K."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Langeberg L.K."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Bear M.F."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Bear M.F."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Colledge M."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Colledge M."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Crozier R.A."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Crozier R.A."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Snyder E.M."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Snyder E.M."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Soderling J.A."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/author | "Soderling J.A."xsd:string |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14642282 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |