| http://purl.uniprot.org/citations/14644449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14644449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14644449 | http://www.w3.org/2000/01/rdf-schema#comment | "Hsp105alpha and Hsp105beta are mammalian members of the Hsp105/110 family, a diverged subgroup of the Hsp70 family. Here, we show that Hsp105alpha and Hsp105beta bind non-native protein through the beta-sheet domain and suppress the aggregation of heat-denatured protein in the presence of ADP rather than ATP. In contrast, Hsc70/Hsp40 suppressed the aggregation of heat-denatured protein in the presence of ATP rather than ADP. Furthermore, the overexpression of Hsp105alpha but not Hsp70 in COS-7 cells rescued the inactivation of luciferase caused by ATP depletion. Thus, Hsp105/110 family proteins are suggested to function as a substitute for Hsp70 family proteins to suppress the aggregation of denatured proteins in cells under severe stress, in which the cellular ATP level decreases markedly."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)01292-4"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)01292-4"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Ishihara K."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Ishihara K."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Yamagishi N."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Yamagishi N."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Hatayama T."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/author | "Hatayama T."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/pages | "390-396"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/pages | "390-396"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/title | "Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/title | "Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP."xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/volume | "555"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://purl.uniprot.org/core/volume | "555"xsd:string |
| http://purl.uniprot.org/citations/14644449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14644449 |
| http://purl.uniprot.org/citations/14644449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14644449 |