| http://purl.uniprot.org/citations/14645006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14645006 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen-specific CD4+ effector T cells primarily provide help for B-cell antibody responses and CD8+ cytotoxic T-lymphocyte (CTL) responses. We have found an expanded population of HIV-1 p24-specific, T-cell receptor V beta 17+, CD4+ T lymphocytes, defined by in vitro proliferative and interferon-gamma responses to a 15-mer Gag peptide, in the peripheral blood of an individual with long-term nonprogressive HIV-1 infection. Ex vivo, these cells were CCR5+ and CCR7-, consistent with an effector/memory function. Surprisingly, these cells highly expressed several proteins characteristic of cytotoxic lymphocytes, including TIA-1 (T-cell intracellular antigen 1; GMP-17/NKG7), granzymes A and B, CD161 (NKRP-1), and CD244 (C1.7/2B4). Following in vitro peptide stimulation, these cells produced interleukin 2 (IL-2) and intracellular CD40L, suggesting possible helper function, in addition to induction of perforin and cytotoxicity. A subset of cytomegalovirus (CMV)-specific CD4+ T cells in healthy adults similarly expressed these CTL markers and CCR5, ex vivo. Furthermore, this distinct subset of CD4+ T cells was significantly elevated in healthy CMV-seropositive adults, compared with CMV-seronegative individuals. These results suggest that CCR5+ CD4+ CTL may be a major effector mechanism of the immune response to viral infections in humans. Moreover, expression of CCR5 may render them particularly susceptible to cytopathic effects during progressive HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-08-2765"xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Moore J."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Mackay C.R."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Miranda-Saksena M."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Saksena N.K."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Newton R."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Cooper D.A."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Kelleher A.D."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Zaunders J.J."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Dyer W.B."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/author | "Munier M.L."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/pages | "2238-2247"xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/title | "Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection."xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/14645006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14645006 |
| http://purl.uniprot.org/citations/14645006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14645006 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-14645006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14645006 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-14645006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14645006 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-14645006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14645006 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-14645006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14645006 |