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| http://purl.uniprot.org/citations/14645472 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic strengthening induced by brain-derived neurotrophic factor (BDNF) is associated with learning and is coupled to transcriptional activation. However, identification of the spectrum of genes associated with BDNF-induced synaptic plasticity and the correlation of expression with learning paradigms in vivo has not yet been studied. Transcriptional analysis of BDNF-induced synaptic strengthening in cultured hippocampal neurons revealed increased expression of the immediate early genes (IEGs), c-fos, early growth response gene 1 (EGR1), activity-regulated cytoskeletal-associated protein (Arc) at 20 min, and the secreted peptide VGF (non-acronymic) protein precursor at 3 hr. The induced genes served as prototypes to decipher mechanisms of both BDNF-induced transcription and plasticity. BDNF-mediated gene expression was tyrosine kinase B and mitogen-activated protein kinase-dependent, as demonstrated by pharmacological studies. Single-cell transcriptional analysis of Arc after whole-cell patch-clamp recordings indicated that increased gene expression correlated with enhancement of synaptic transmission by BDNF. Increased expression in vitro predicted elevations in vivo: VGF and the IEGs increased after trace eyeblink conditioning, a hippocampal-dependent learning paradigm. VGF protein was also upregulated by BDNF treatment and was expressed in a punctate manner in dissociated hippocampal neurons. Collectively, these findings suggested that the VGF neuropeptides may regulate synaptic function. We found a novel function for VGF by applying VGF peptides to neurons. C-terminal VGF peptides acutely increased synaptic charge in a dose-dependent manner, whereas N-terminal peptide had no effect. These observations indicate that gene profiling in vitro can reveal new mechanisms of synaptic strengthening associated with learning and memory."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-34-10800.2003"xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Kuroiwa M."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Black I.B."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Thakker-Varia S."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Alder J."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Shors T.J."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Plummer M.R."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/author | "Bangasser D.A."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/pages | "10800-10808"xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/title | "Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/14645472 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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