| http://purl.uniprot.org/citations/14645534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14645534 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed during development, K-ras 4A expression is regulated temporally and spatially and occurs in adult kidney, intestine, stomach, and liver. In the present study, the pattern of K-ras 4A expression was examined in a wide range of wild-type adult mouse tissues, and gene targeting was used to generate K-ras 4A-deficient mice to examine its role in development. It was found that K-ras 4A is also expressed in uterus, lung, pancreas, salivary glands, seminal vesicles, bone marrow cells, and cecum, where it was the major K-Ras isoform expressed. Mating between K-ras(tmDelta4A/+) mice produced viable K-ras(tmDelta4A/tmDelta4A) offspring with the expected Mendelian ratios of inheritance, and these mice expressed the K-ras 4B splice variant only. K-ras(tmDelta4A/tmDelta4A) mice were fertile and showed no histopathological abnormalities on inbred (129/Ola) or crossbred (129/Ola x C57BL/6) genetic backgrounds. The results demonstrate that K-Ras 4A, like H- and N-Ras, is dispensable for normal mouse development, at least in the presence of functional K-Ras 4B."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.24.9245-9250.2003"xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Melton D.W."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Arends M.J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Harrison D.J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Doig J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "O'Sullivan M.J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Williamson D.J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Hooper M.L."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Ritchie A.M."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Plowman S.J."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/author | "Patek C.E."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/pages | "9245-9250"xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/title | "While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable."xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14645534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14645534 |
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| http://purl.uniprot.org/uniprot/#_P32883-mappedCitation-14645534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14645534 |