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http://purl.uniprot.org/citations/14645850http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14645850http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14645850http://www.w3.org/2000/01/rdf-schema#comment"Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus. A clinical isolate of S. aureus with high-level resistance to vancomycin (minimal inhibitory concentration = 1024 microg/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn1546 (vanA) was integrated. Additional elements on the plasmid encoded resistance to trimethoprim (dfrA), beta-lactams (blaZ), aminoglycosides (aacA-aphD), and disinfectants (qacC). Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.org/dc/terms/identifier"doi:10.1126/science.1090956"xsd:string
http://purl.uniprot.org/citations/14645850http://purl.org/dc/terms/identifier"doi:10.1126/science.1090956"xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Gill S.R."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Gill S.R."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Kolonay J.F."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Kolonay J.F."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Shetty J."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Shetty J."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Tenover F.C."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Tenover F.C."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Clark N.C."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Clark N.C."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Clewell D.B."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Clewell D.B."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Flannagan S.E."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Flannagan S.E."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Killgore G.E."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Killgore G.E."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"McDougal L.K."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"McDougal L.K."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Weigel L.M."xsd:string
http://purl.uniprot.org/citations/14645850http://purl.uniprot.org/core/author"Weigel L.M."xsd:string