| http://purl.uniprot.org/citations/14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14647425 | http://www.w3.org/2000/01/rdf-schema#comment | "The Dok adaptor family of proteins binding to RasGAP, consisting of Dok-1 and Dok-2, are critical regulators in cell proliferation. These molecules are partners and/or substrates of different protein tyrosine kinases considered as oncoproteins. Here, we show that Dok-1 and Dok-2 are the major tyrosine-phosphorylated proteins associated to Tec, a protein tyrosine kinase expressed in T cells. Furthermore, we evaluate the effect of Dok-1 or Dok-2 on Tec-mediated signalling pathways in T cells. Here, we provide evidence that Dok-1 and Dok-2 proteins are involved in a negative feedback regulation of Tec via a downregulation of its tyrosine phosphorylation and downstream signalling pathways including the Ras pathway. Either Dok-1 or Dok-2 therefore represents a mean of potent retrograde control for protein tyrosine kinase signalling, and then possibly of tumor development."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207283"xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Collette Y."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Olive D."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Duplay P."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Nunes J.A."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Pastor S."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Gerard A."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Favre C."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Garcon F."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/author | "Nemorin J.G."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/pages | "1594-1598"xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/title | "Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14647425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14647425 |
| http://purl.uniprot.org/citations/14647425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14647425 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW01-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW29-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |
| http://purl.uniprot.org/uniprot/#_B4DKQ6-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |
| http://purl.uniprot.org/uniprot/#_A8K7W1-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |
| http://purl.uniprot.org/uniprot/#_B3KP83-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |
| http://purl.uniprot.org/uniprot/#_B4DJN1-mappedCitation-14647425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14647425 |