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http://purl.uniprot.org/citations/14651137http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14651137http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To analyze the role of HLA genotypes in persistence of chronic hepatitis B in Western India.

Methods

HLA genotyping for class II-DR was done in 26 subjects having chronic hepatitis B infection (HBsAg positive) and in 100 healthy controls. Statistics were done using Halden's modification of Woolf's formula.

Result

Significant association of chronic hepatitis B infection was found for class II-DR antigens DRB1*15XX (57.6 vs. 25%) and DRB1*11XX (23 vs. 4%). DRB1*13XX (0 vs. 19%) was negatively associated with chronic hepatitis B infection.

Conclusion

HLA phenotype, which varies with different regions, is one of the factors in persistence of hepatitis B infection. Our study supports negative association of DRB1*13XX to persistence of HBV. Also there may be role of DRB1*11XX and DRB1*15XX in persistence of HBV and development of chronic HBV hepatitis."xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/author"Patel N.D."xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/author"Amarapurpar D.N."xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/author"Kankonkar S.R."xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/name"J Assoc Physicians India"xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/pages"779-781"xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/title"HLA class II genotyping in chronic hepatitis B infection."xsd:string
http://purl.uniprot.org/citations/14651137http://purl.uniprot.org/core/volume"51"xsd:string
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