| http://purl.uniprot.org/citations/14651848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14651848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14651848 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NF-kappaB is critical for setting the cellular sensitivities to apoptotic stimuli, including DNA damaging anticancer agents. Central to NF-kappaB signaling pathways is NEMO/IKKgamma, the regulatory subunit of the cytoplasmic IkappaB kinase (IKK) complex. While NF-kappaB activation by genotoxic stress provides an attractive paradigm for nuclear-to-cytoplasmic signaling pathways, the mechanism by which nuclear DNA damage modulates NEMO to activate cytoplasmic IKK remains unknown. Here, we show that genotoxic stress causes nuclear localization of IKK-unbound NEMO via site-specific SUMO-1 attachment. Surprisingly, this sumoylation step is ATM-independent, but nuclear localization allows subsequent ATM-dependent ubiquitylation of NEMO to ultimately activate IKK in the cytoplasm. Thus, genotoxic stress induces two independent signaling pathways, SUMO-1 modification and ATM activation, which work in concert to sequentially cause nuclear targeting and ubiquitylation of free NEMO to permit the NF-kappaB survival pathway. These SUMO and ubiquitin modification pathways may serve as anticancer drug targets."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00895-x"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00895-x"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Wu Z.H."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Wu Z.H."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Huang T.T."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Huang T.T."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Wuerzberger-Davis S.M."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/author | "Wuerzberger-Davis S.M."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/pages | "565-576"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/pages | "565-576"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/title | "Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/title | "Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/14651848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14651848 |
| http://purl.uniprot.org/citations/14651848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14651848 |